Safety Pharmacology / Telemetry

LAB Research is an industry leader in GLP compliant safety pharmacology, offering fully-validated test systems to support international regulatory requirements (e.g. ICH S7A & ICH S7B).  A large, dedicated team of experienced veterinary scientists & surgeons is involved in all aspects of validation and study conduct and is supported by a network of recognized experts in cardiovascular, respiratory and central nervous system physiology and pharmacology.  LAB Research offers a variety of large and small animal models, using state-of-the-art technologies, to complete the safety pharmacology core battery of studies.  Supplementary or follow-up studies are offered using tailored solutions for comprehensive pharmacodynamic investigations.

As part of its services in Safety Pharmacology, LAB Research offers the industry’s largest single site telemetry capability, making us an industry leader in the conduct of conscious cardiovascular safety pharmacology studies.

Validated computerized ECG analysis, combined with expert review by Board Certified Veterinary Cardiologists ensures that electrocardiographic and hemodynamic data are thoroughly and expertly evaluated.  Our team benefits from over twenty years of experience using various models for in depth cardiovascular investigations.

In-house data, obtained with various positive control drugs, is also available to better assess pharmacodynamic responsiveness, sensitivity and reproducibility of the cardiovascular, respiratory and neurological safety pharmacology models.

Safety Pharmacology Core Battery
 Cardiovascular System
 Respiratory System
 Central Nervous System

Follow-up Studies
 Fully instrumented cardiovascular models
 Pulmonary arterial pressure
 Complete respiratory mechanics
 Blood gases and blood pH
 Electroretinography

Supplemental Safety Pharmacology Studies
 Gastrointestinal safety pharmacology
 Renal and urinary models

Equipment and Infrastructure
 Data Science International Telemetry System
 Industry’s largest telemetry system
 Hans Rudolph & Scireq respiratory system
 Dedicated rooms for safety pharmacology
 Multiple surgical suites
 Imaging (X-ray and fluoroscopy)

Quantitative Parameters
• Arterial blood pressure (systolic, diastolic, mean)
• Left ventricular pressure
• ECG intervals
• Activity
• Core body temperature
• Pleural pressure
• Biopotentials (ECG, EEG, EMG)

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For more information, please contact LAB Research Canada toll free: +(1) 888-353-2240, direct line: + (1) 450-973-2240 or email: safetypharm @ labresearch.com (remove spaces)